seqMINER: an integrated ChIP-seq data interpretation platform
نویسندگان
چکیده
منابع مشابه
seqMINER: an integrated ChIP-seq data interpretation platform
In a single experiment, chromatin immunoprecipitation combined with high throughput sequencing (ChIP-seq) provides genome-wide information about a given covalent histone modification or transcription factor occupancy. However, time efficient bioinformatics resources for extracting biological meaning out of these gigabyte-scale datasets are often a limiting factor for data interpretation by biol...
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ChIP-chip and ChIP-seq are powerful technologies to study transcriptional regulation in complex genomes, however, mining information from the huge datasets generated by these highthroughput technologies remains to be a non-trivial task. To analyze a ChIP-chip experiment, one usually starts with data exploration and then goes through normalization, binding region detection, adding gene annotatio...
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Regulatory proteins can bind to different sets of genomic targets in various cell types or conditions. To reliably characterize such condition-specific regulatory binding we introduce MultiGPS, an integrated machine learning approach for the analysis of multiple related ChIP-seq experiments. MultiGPS is based on a generalized Expectation Maximization framework that shares information across mul...
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The mapping of DNA-protein interactions is crucial for a full understanding of transcriptional regulation. Chromatin-immunoprecipitation followed by massively parallel sequencing (ChIP-seq) has become the standard technique for analyzing these interactions on a genome-wide scale. We have developed a software system called CASSys (ChIP-seq data Analysis Software System) spanning all steps of ChI...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2010
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkq1287